SHORT COMMUNICATION
Not peer reviewed - submission record only

A Bio-Mimetic Approach: Non-adverse Effects of Zinc Oxide Nanoparticles with Probiotic Isolate (Lactiplantibacillus plantarum)

Kumar Vasuki1 Balasubramanian Kaleeswaran1 , * iD Rengarajan Murugesan2 , * iD Authors Info & Affiliations
The Open Biotechnology Journal • 29 Jun 2026 • SHORT COMMUNICATION
Note: This record reflects a manuscript recently submitted to the journal above. It is not a final publication, and no DOI or other citable identifier is assigned to it.*

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Abstract

Introduction

Green nanotechnology utilises biological systems to produce nanoparticles, offering environmentally friendly and sustainable alternatives to traditional chemical methods.

Methods

Biosynthesis of zinc oxide nanoparticles (ZnO NPs) using novel probiotic bacteria from the gut of the snail Pila globosa-derived probiotics (Lactiplantibacillus plantarum)-has promising applications in the development of health-related feed supplements. ZnO:LP NPs represent a significant advancement in the biomimetic approach for enhancing biocompatibility, structural uniformity, and antimicrobial effectiveness.

Results

Characterization of the synthesised nanoparticles, conducted using techniques such as Ultraviolet-Visible-Near Infrared (UV-Vis-NIR) spectroscopy, X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM), confirmed the successful formation of a hexagonal wurtzite structure. Biological assays were performed to investigate the synthesized nanoparticles, revealing significant antibacterial and cytotoxic activities.

Discussion

This research highlights the promising applications of probiotic nanoparticles.

Conclusion

This research highlights the potential of probiotic-based nanoparticles for the development of comprehensive feed supplements with nutraceutical and nutri-biotechnological applications, as well as their implications for the food and healthcare industries.

Keywords: Zinc oxide, Nanoparticles, Lactiplantibacillus, Feed supplement, Cytotoxicity, Green nanotechnology.
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